Cancer rates in medieval Britain around ten times higher than previously thought, study suggests

The first study to use X-rays and CT scans to detect evidence of cancer among the skeletal remains of a pre-industrial population suggests that between 9-14% of adults in medieval Britain had the disease at the time of their death.

This puts cancer prevalence in a time before exposure to tumour-inducing chemicals from industry and tobacco at around ten times higher than previously thought, according to researchers.

Prior research into historic cancer rates using the archaeological record has been limited to examining the bone exterior for lesions. It suggested that cancer was rare, affecting less than 1% of the population.

A team led by the University of Cambridge have now coupled visual inspection with radiological imaging to analyse 143 skeletons from six medieval cemeteries in and around the city of Cambridge, UK, dating from the 6th to the 16th century.

The findings of the study are published today in the journal Cancer.

“The majority of cancers form in soft tissue organs long since degraded in medieval remains. Only some cancer spreads to bone, and of these only a few are visible on its surface, so we searched within the bone for signs of malignancy,” said lead author Dr. Piers Mitchell, who conducted the research as part of the ‘After the Plague’ project.

“Modern research shows a third to a half of people with soft tissue cancers will find the tumour spreads to their bones. We combined this data with evidence of bone metastasis from our study to estimate cancer rates for medieval Britain.”

We think the total proportion of the medieval population that probably suffered with a cancer somewhere in their body was between nine and fourteen percent,” said Mitchell, from Cambridge University’s Department of Archaeology.

“Using CT scans we were able to see cancer lesions hidden inside a bone that looked completely normal on the outside,” said study co-author and After the Plague researcher Dr. Jenna Dittmar.

“Until now it was thought that the most significant causes of ill health in medieval people were infectious diseases such as dysentery and bubonic plague, along with malnutrition and injuries due to accidents or warfare.”

“We now have to add cancer as one of the major classes of disease that afflicted medieval people,” Dittmar said.

However, the researchers point out that in modern Britain some 40-50% of people have cancer by the time they die, making the disease 3-4 times more common today than the latest study suggests it was during medieval times.

They say that a variety of factors likely contribute to contemporary rates of the disease, such as the effects of tobacco, which began to be imported into Britain in the 16th century with the colonising of the Americas.

The researchers also point to the cancerous effects of pollutants that have become ubiquitous since the industrial revolution of [ … ]

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