Unfortunately, cancer also loves glucose. It loves it so much that cancer cells are willing to burn through glucose as quickly as possible, similar to the way muscle cells burn through glucose during rigorous exercise (a process known as glycolysis). Cancer cells also supplement their “diet” with glutamine, an amino acid found in proteins.
In order to implement this metabolic shift, cancer cells put more glucose transporters (which import glucose) into their membranes and rely on glutamine to satisfy other nutritional requirements. This has led to the hypothesis that blocking the import of glucose and the metabolism of glutamine could serve as powerful weapons against cancer. In other words, starving cancer cells of their favorite foods could inhibit tumor growth.
Starving Cancer Cells of Glucose and Glutamine
Reporting in the journal Cell Chemical Biology, a team of researchers led by Elena Reckzeh describe the discovery of a new, high-potency molecule (which they called Glutor) that blocked several varieties of the glucose transport protein. This is significant because previous inhibitors were low potency and/or only blocked one kind of glucose transport protein.
The first image depicts the molecular mechanism of their proposed chemotherapeutic strategy. The first part of the strategy involves treating cancer with Glutor, which will shut down glucose metabolism. Indeed, the authors showed that 44 different cancer cell lines were potently inhibited by Glutor in vitro. Non-cancerous cell lines were not inhibited…[ ]