Gender dysphoria (GD) of childhood describes apsychological condition in which a child experiences markedincongruence between his experienced gender and thegender associated with his biological sex. When this occursin the prepubertal child, GD resolves in the vast majority ofpatients by late adolescence. Currently there is a vigorousalbeit suppressed debate among physicians, therapists, andacademics regarding what is fast becoming the new treatmentstandard for GD in children. Modeled after a paradigmdeveloped in the Netherlands, it involves pubertal suppressionwith gonadotropin releasing hormone (GnRH) agonistsfollowed by the use of cross-sex hormones—a combinationthat will result in the sterility of minors. A review of the currentliterature suggests that this protocol is rooted in an unscientificgender ideology, lacks an evidence base, and violates the longstanding ethical principle of “First do no harm.